Announcement PDF Rule 3.19A.1 Appendix 3X Initial Director's Interest Notice Information or documents not available now must be given to ASX as soon as available. Information and documents given to ASX becomes ASX's property and may be made public. Introduced 30/9/2001. We (the entity) give ASX the following information under listing rule 3.19.A.1 and as agent for the director for the purposes of section 205G of the Corporations Act. Appendix 3X Initial Director's Interest Notice Name of entity Alterity Therapeutics Limited ABN 37 080 699 065 Name of director David Stamler Date of appointment 21 November 2025 Part 1 - Director's relevant interests in securities of which the director is the registered holder In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust Note: In the case of a company, interests which come within paragraph (i) of the definition of "notifiable interest of a director" should be disclosed in this part. Number & class of securities 11,688,312 - FULLY PAID ORDINARY SHARES 2,380,952 - LISTED OPT EXP 31/08/2026 @ $0.01 1,515,152 - LISTED OPT EXP 26/02/2027 @ $0.028 40,000,200 - UNLISTED OPT EXP 21/03/2029 @ US$0.0030 91,392,720 - UNLISTED OPT EXP 06/01/2026 @ $0.0320 290,400,000 - UNLISTED OPT EXP 08/08/2030 @ US$0.0086 Part 2 - Director's relevant interests in securities of which the director is not the registered holder In the case of a trust, this includes interests in the trust made available by the responsible entity of the trust Name of holder & nature of interest Number & class of Securities Note: Provide details of the circumstances giving rise to the relevant interest. HSBC CUSTODY NOMINEES (AUSTRALIA) LIMITED 133,333 - AMERICAN DEPOSITARY SHARES (equivalent to 79,999,800 FULLY PAID ORDINARY SHARES) Part 3 - Director's interests in contracts Note: In the case of a company, interests which come within paragraph (ii) of the definition of "notifiable interest of a director" should be disclosed in this part. Detail of contract N/A Nature of interest N/A + See chapter 19 for defined terms. 11/03/2002 Appendix 3X Page 1 Appendix 3X Initial Director's Interest Notice Name of registered holder (if issued securities) N/A No. and class of securities to which interest relates N/A + See chapter 19 for defined terms. Appendix 3X Page 2 11/03/2002