Announcement PDF 604 Page 1 of 2 15 July 2001 Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder To Company Name/Scheme Alterity Therapeutics Limited ACN/ARSN 080 699 065 1. Details of substantial holder (1) The Bank of New York Mellon Corporation (BNYMC) and each Group Entity listed in Annexure A (Group Entity),(together BNYMC Group) Name ACN/ARSN (if applicable) There was a change in the interests of the substantial holder on 08/January/2024 The previous notice was given to the company on 21/December/2023 The previous notice was dated 20/December/2023 2. Previous and present voting power The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows: Class of securities (4) Ordinary shares Previous notice Present notice Person’s votes Voting power (5) Person’s votes Voting power (5) 1,588,872,148 56.70% 1,594,069,348 41.82% *See Note 1 in Annexure C 3. Changes in relevant interests Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows: Date of change Person whose relevant interest changed Nature of change (6) Consideration given in relation to change (7) Class and number of securities affected Person's votes affected See Annexure B 4. Present relevant interests Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows: Holder of relevant interest See Annexure C Registered holder of securities Person entitled to be registered as holder (8) Nature of relevant interest (6) Class and number of securities Person's votes 604 Page 2 of 2 15 July 2001 5. Changes in association The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows: Name and ACN/ARSN (if applicable) Nature of association BNYMC and each Group Entity Each Group Entity is an associate of BNYMC pursuant to section 12(2)(a) of the Corporations Act 2001 (Cth) as each entity is directly or indirectly owned and controlled by BNYMC. 6. Addresses The addresses of persons named in this form are as follows: Name Address The Bank of New York Mellon Corporation 240 Greenwich Street, New York, NY 10286 USA Each Group Entity 240 Greenwich Street, New York, NY 10286 USA Signature print name sign here Andrew Weiser capacity Attorney-In-Fact date 09/January/2024 Annexure A This is Annexure A of 1 page referred to in Form 604 Notice of Change of Interests of Substantial Holder given by The Bank of New York Mellon Corporation and its related bodies corporate The Bank of New York Mellon Corporation is the ultimate parent company of a corporate group comprised of a large number of operating and holding companies. Details of the entities directly owned and controlled by The Bank of New York Mellon Corporation are listed below.  The Bank of New York Mellon print name Andrew Weiser capacity______ Attorney-In-Fact sign here date 09/January/2024_____________ Annexure B This is Annexure B of 1 page referred to in Form 604 Notice of Change of Interests of Substantial Holder given by The Bank of New York Mellon Corporation and its related bodies corporate Changes in relevant interests Date of change Person whose relevant interest changed Nature of Change Consideration given in relation to change 8-Jan-2024 The Bank of New York Mellon Deposit of securities N/A Print Name - Andrew Weiser Sign Here Capacity - Attorney-In-Fact Date - 09 January 2024 Class and number of securities affected (Ordinary Shares) 5,197,200 Person's votes affected 5,197,200 Annexure C This is Annexure C of 1 page referred to in Form 604 Notice of Change of Interests of Substantial Holder given by The Bank of New York Mellon Corporation and its related bodies corporate Present relevant interests Holder of relevant interest The Bank of New York Mellon (BNYM) Nature of relevant interest Class and number of securities Remote Interest Held Under Deposit Agreement 1,594,069,348 ordinary shares Relevant interest under section 608(1)(c) of the Corporations Act 2001 (Cth) arising from BNYM having the limited power to dispose of, or control the exercise of a power to dispose of, securities deposited with or held by BNYM (or its custodian or agent) in its capacity as depositary administering an ADR program for Alterity Therapeutics Limited (Company) under the Deposit Agreement dated January 2, 2008 between the Company, holders of American depositary receipts (ADRs) and BNYM (Deposit Agreement). [*See Note 1 below]. BNYMC Group (other than BNYM) 1,594,069,348 Relevant interest under section 608(3)(a) and/or section 608(3)(b) of the Corporations Act 2001 (Cth) ordinary shares being a relevant interest held through a body corporate (namely BNYM) in which the voting power of each other entity in the BNYMC Group is above 20%, or that each other entity in the BNYMC Group controls. [*See Note 1 and Note 2 below] NOTES: *Note 1: Of the total of 1,594,069,348 securities in which the BNYMC Group has a relevant interest, BNYM has a relevant interest in 1,594,069,348 securities as depositary for Alterity Therapeutics Limited ADR program administered under the Deposit Agreement. BNYM's relevant interest in these securities arises as a result of the Deposit Agreement containing rights for BNYM to dispose of securities held under the ADR program in limited circumstances. Under the Deposit Agreement, ADR holders retain their rights to dispose of those securities and to give voting instructions for the exercise of voting rights attached to the securities. BNYMC Group's power to vote or dispose of these securities is qualified accordingly. *Note 2: Each Group Entity is a direct or indirect wholly owned subsidiary of BNYMC, the ultimate parent company. Other than BNYM in respect of 1,594,069,348 securities (of which BNYM's power to only dispose of 1,594,069,348 securities is limited – see Note 1), none of the BNYMC Group entities are entitled to be registered as holder of the securities and their power to vote or dispose of the securities is qualified accordingly. print name Andrew Weiser capacity_ Attorney-In-Fact sign here date 09/January/2024__